Rheumatoid Arthritis (RA), an autoimmune disorder develops pain, synovitis, cartilage degradation and bony erosion along with showing the symptoms of depression among the patients. Recent studies have shown that mind body interventions like yoga is effective improving quality of life and depression among patients in such autoimmune conditions. This study has shown improvement of systematic inflammatory markers and co-morbid depression among the yoga group of the active RA patients.