Engaging in exercise has the remarkable capacity to revitalize stem cells and enhance tissue revitalization in aging mice. This research delved into the cellular and molecular alterations occurring in a range of stem cell varieties post-exercise. It involved the elderly and young mice with aerobic exercise and analysing their stem cells at the transcriptomic level. The study demonstrated that exercise mitigates the heightened inflammation associated with aging while enhancing communication between cells, particularly via immune cells. Furthermore, it exerts a significant influence on the composition and gene expression of immune cells in both the bloodstream and tissues. In summary, this investigation provides a comprehensive insight into how exercise affects various types of aging stem cells and their surrounding environments.

Exercise

Aging

Inflammation

scRNA Sequencing

Regeneration

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